The Blazeman Foundation for ALS has announced its most recent gift to fund research into Amyotrophic Lateral Sclerosis (ALS) at Wake Forest Baptist Medical Center, raising its total commitment to nearly $250,000. Read more.
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Support BMF while shopping at Amazon
The Blazeman Foundation for ALS is now a charity on Amazon Smiles. Help support the BMF when shopping on Amazon. If you shop on Amazon, you can direct that .5% of what you spend goes to a charity. If you go to smile.amazon.com, it will allow you to search for a charity. Type in “Blazeman” and it will come up. Select it and shop!!
Research Update from the Rodal Lab (Brandeis University)
Significant progress has been made this year in deciphering where receptors have been shifted in the ALS model flies, and why. While we had previously discovered that growth signaling receptors were lost from an early endosome in the ALS model flies, we did not yet know to where they had been diverted. This year, we discovered that the receptors had been shifted to a recycling endosome compartment (which is responsible for sending receptors back to the cell
surface). Update on Brandeis project, including next steps.
Wake Forest Finding Success with the Hsp70 project
Researchers at Wake Forest have found a new treatment that may delay the onset of symptoms and increase the lifespan for those who are afflicted with ALS. The study was conducted in the mutant SOD1 mouse model of ALS and <a href=”/uploaded/Research WFU/Hsp70 project continue request Sept 2015.pdf”>plan to continue</a> to modify purification protocols, dosage studies in mice, and seek independent confirmation of effect. These studies will provide essential pre-clinical results so they can apply to move forward to patient studies (apply for an IND with the USFDA).
Another Year of Funding (Wake Forest)
Wake Forest Baptist Health intends to provide <a href=”/uploaded/Research WFU/WFU March 2015.pdf”>another year of funding</a> for the HSP70 project in Dr. Carol Milligan’s lab. This money is intended to help cover the cost of a dose response trial in mice and to develop a reliable detection assay for the HSP70 protein.