Significant progress has been made this year in deciphering where receptors have been shifted in the ALS model flies, and why. While we had previously discovered that growth signaling receptors were lost from an early endosome in the ALS model flies, we did not yet know to where they had been diverted. This year, we discovered that the receptors had been shifted to a recycling endosome compartment (which is responsible for sending receptors back to the cell
surface). Update on Brandeis project, including next steps.
