The Mulligan Lab at Wake Forest University was working on a dose response study of the Hsp70 protein with the hopes that their ALS scientists and clinicians would be able to start to design initial clinical trials in patients. Unexpectedly, the protein does not prevent neuromuscular junction denervation in the mouse model of ALS.
Tissue donation, harvesting, and storage is a much needed aspect in the WaronALS and finding a cure. Your fundraising has allowed the BMF to purchase two large (-)80 degree Celsius freezers that will allow University of Maryland Brain and Tissue Bank to continue to recover tissue from the generous ALS community. Dedication of these freezers in Jon’s memory took place on August 30th, Jon’s birthday. More information available in our newsletter on the Research page.
A warm thank you to all the participants in the 2017 Death Ride Tour VIII in Colorado. The BMF received a $15,000 donation so that we can continue to support innovative research and the ALS tissue acquisition program. Visit their website to learn about how you can participate in the 2017 Death Ride Tour Fall Blaze happening this October in Massachusetts.
Your donation dollars go directly to supporting ALS research. One means of support is through the Blazeman Post-Doc position at Brandeis University. Training the next generation of ALS researchers is instrumental for finding a cure.
In a collaborative study between the National Institute of Health, the University of Maryland and the University of Michigan, researchers used a 7 tesla (high intensity) MRI to image the donated brains from donors with ALS and compared the findings to those obtained from donors without ALS. The spinal cord, brain and muscle samples used in the study were recovered by the University of Maryland Brain and Tissue Bank, which is supported by a grant from the Blazeman Foundation. Dr. Kwan (co-author) provides a summary of the study. For a more in-depth analysis, read the journal article from NeuroImage: Clinical 15 (2017) 200-208.
Dr. Rodal’s lab continues to investigate how TDP-43 leads to growth signaling defects in the fruit fly model as well as continuing to pursue the role of calcium channels in their mammalian models of ALS. Their progress report summarizes the past four years of research supported by the BMF and gives a look into next steps (how relevant are these pathways for progression of cellular pathology in human patients?). For a more detailed version of their work, please see the unabridged version.
BMF for ALS “Postdoctural Fellow” will examine a Protein’s Effect in Human Cells
Tissue donation is one of the greatest contributions that people can and have made to help find a cure for ALS. Proper storage of tissue is necessary, so to help in the fight the BMF has extended its grant to University of Maryland’s Brain and Tissue Bank for the purchase of additional freezers devoted to ALS research. Thank you.
was held at Soul Cycle, Bronxville, NY on Sunday, March 19th. A special thank you to Phil Gormley, who has organized this event since the beginning! Thank you for all you have done. Thank you for all who’ve participated from year one to now year 10, (unbelievable)… You are the constant warriors in the WarOnALS®. Only by making a continuous and concerted effort through “research” on all levels, will this “hideous disease-ALS” be destroyed.
Today (March 16) your support goes 10x as far! Amazon is celebrating its #1 ranking in customer satisfaction by the ACSI! Today, March 16, Amazon will donate 5% (10 times the usual donation rate) of the price of your eligible AmazonSmile purchases to Blazeman Foundation for ALS. Get started at smile.amazon.com/ch/20-8526311.